Conjugation reactions

US8877892B2 · kind B2 · utility

Assignee

• INNOVA BIOSCIENCES LTD. · GB

Inventors

• Nicholas Gee · Cambridge, GB
• Annamaria Draghi · Borgo Valsugana, IT

Key dates

• Filing date: Mar 15, 2011
• Grant date: Nov 4, 2014
• Expiry date: Jun 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/00
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

We describe methods that allow either carbodiimides or other carboxyl-reactive substances to be mixed with solutions of carboxylic acids or phosphates or amines or combinations thereof, so as to form a homogeneous mixture which is then dried, preferably in a freeze drying process. The mixture is then contacted with an entity, which preferably involves the dissolution of the mixture with a buffered solution of the entity, so as to initiate a conjugation reaction between the entity and a component in the mixture.