Patent · US Active

Pegylated cyclopamine analogue, preparation method and uses thereof

US8877928B2 · kind B2 · utility

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1References

16Claims

0Family size

Assignee

SHANDONG UNIVERSITY · CN

Inventors

Chun Song · Shandong, CN
Chengzhi Zhang · San Diego, US
Xin Zhao · Austin, US
Zhao Hu · Nanjing, CN
Xiuling Xu · Beijing, CN
Youzhong Zhang · Dongguan, CN
Mingyi Wang · Beijing, CN
Zhijun Sun · Beijing, CN

Key dates

Filing date	Feb 25, 2011
Grant date	Nov 4, 2014
Priority date	—
Expiry date	Feb 25, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08L2203/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.