Delivery of nucleic acid-like compounds

US8883200B2 · kind B2 · utility

Assignee

• SUTTER WEST BAY HOSPITALS · US

Inventors

• Keelung Hong · Mill Valley, US
• Wei Zheng · Las Vegas, US
• Daryl C. Drummond · Lincoln, US
• Dmitri B. Kirpotin · San Francisco, US
• Mark E. Hayes · Mill Valley, US

Key dates

• Filing date: Jul 11, 2013
• Grant date: Nov 11, 2014
• Expiry date: Jul 11, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.