Polyoxazolines with inert terminating groups, polyoxazolines prepared from protected initiating groups and related compounds

US8883211B2 · kind B2 · utility

Assignee

• Serina Therapeutics, Inc. · US

Inventors

• Michael D. Bentley · Huntsville, US
• J. Milton Harris · Huntsville, US
• Michael Reif · Hirschau, DE
• Rainer Jordon · Munich, DE
• Kunsang Yoon · Madison, US

Key dates

• Filing date: Jul 10, 2009
• Grant date: Nov 11, 2014
• Expiry date: Mar 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L79/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.