Single-chain insulin
US8883449B2 · kind B2 · utility
20Cited by
4References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 15, 2008 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Oct 15, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to single-chain insulin having insulin activity comprising a B- and an A-chain or a modified B- and A-chain connected by a connecting peptide of from 6-11 amino acids. The single-chain insulins will have biological insulin activity and an IGF-1 receptor affinity similar to or lower than that of human insulin and a high physical stability. The single-chain insulin may contain at least one basic amino acid residues in the connecting peptide. The single-chain insulins may also be acylated in one or more Lys residues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.