Patent · US Active

Expandable cell source of neuronal stem cell populations and methods for obtaining and using them

US8883502B2 · kind B2 · utility

13Cited by

4References

13Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Kang Zhang · San Diego, US
Sheng Ding · San Diego, US

Key dates

Filing date	Sep 9, 2011
Grant date	Nov 11, 2014
Priority date	—
Expiry date	Sep 9, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/45
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides methods for obtaining neural stem cells from a mammalian embryonic or inducible pluripotent stem cell population comprising culturing mammalian embryonic or inducible pluripotent stem cells in a cell culture medium having a leukemia inhibitory factor (LIF), an inhibitor of glycogen synthase kinase 3 (GSK3), and an inhibitor of transforming growth factor β (TGF-β) under suitable conditions and obtaining isolated neural stem cells therefrom.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.