Kits comprising linear DNAs for sustained polypeptide expression using synthetic, modified RNAs
US8883506B2 · kind B2 · utility
153Cited by
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8Claims
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Key dates
| Filing date | Aug 21, 2012 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Oct 1, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.