Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells
US8883507B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Oct 18, 2006 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Oct 18, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16322
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.