Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs
US8883735B2 · kind B2 · utility
7Cited by
1References
34Claims
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Key dates
| Filing date | Nov 2, 2012 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Nov 2, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.