Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity
US8883751B2 · kind B2 · utility
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Key dates
| Filing date | Jul 30, 2008 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Sep 10, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/113
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.