Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors

US8883789B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Annekatrin Heimann · Biberach, DE
• Georg Dahmann · Biberach an der Riß, DE
• Marc Grundl · Biberach an der Riß, DE
• Stephan Georg Mueller · Warthausen, DE
• Bernd Wellenzohn · Friedrichshafen, DE

Key dates

• Filing date: Dec 10, 2012
• Grant date: Nov 11, 2014
• Expiry date: Dec 28, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula Itheir use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. R1, R2, R3, R4, Q have meanings given in the description.