Tubulin inhibitors and methods of using the same
US8883793B2 · kind B2 · utility
7Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 29, 2011 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Dec 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof:R2—Y—Z-Q-A-R1 Formula (I)wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.