Azole derivatives as WTN pathway inhibitors

US8883827B2 · kind B2 · utility

Assignee

• Oslo University Hospital HF · NO

Inventors

• Daniel Holsworth · San Diego, US
• Jo Waaler · Oslo, NO
• Ondrej Machon · Praha, CZ
• Stefan Krauss · Eidsvoll verk, NO

Key dates

• Filing date: Jun 7, 2010
• Grant date: Nov 11, 2014
• Expiry date: Jun 7, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.