Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy

US8883839B2 · kind B2 · utility

Assignees

• Abbott Laboratories · US
• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Frauke Pohlki · Wiesbaden, DE
• Udo Lange · Ludwigshafen, DE
• Wilhelm Amberg · Ludwigshafen, DE
• Michael Ochse · Wiesbaden, DE
• Berthold Behl · Ludwigshafen, DE
• Charles W. Hutchins · Libertyville, US

Key dates

• Filing date: Aug 10, 2011
• Grant date: Nov 11, 2014
• Expiry date: Dec 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to tetraline and indane derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such tetraline and indane derivatives, and the use of such tetraline and indane derivatives for therapeutic purposes. The tetraline and indane derivatives are GlyT1 inhibitors.