Radioprotective agents

US8883852B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Michael W. Epperly · Pittsburgh, US
• Joel S. Greenberger · Dorpsstraat, US
• Jianfei Jiang · Pittsburgh, US
• Valerian Kagan · Pittsburgh, US
• John S. Lazo · Charlottesville, US
• Peter McDonald · Melbourne, AU

Key dates

• Filing date: Oct 21, 2009
• Grant date: Nov 11, 2014
• Expiry date: Aug 16, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.