Patent · US Active

N-substituted benzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation

US8883853B2 · kind B2 · utility

1Cited by
9References
20Claims
0Family size

Assignee

Inventor

Key dates

Filing dateMar 6, 2009
Grant dateNov 11, 2014
Priority date—
Expiry dateSep 10, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07F3/003
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Compounds for use in the treatment or prophylaxis of pain, including acute and chronic pain (e.g., nociceptive pain, neuropathic pain, headaches, migraine), represented by general formula (I) in which: the dotted line represents a single or a double bond; and R5 and R5′ are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is -0-, —CH2O—, —CH2CH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; Z is —CH2CH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is an integer of O or 1; and n is an integer of 0-50. The compounds of the invention are also effective for reducing inflammation and may be used alone or in combination with other analgesics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.