Hexenone compounds and medical use thereof

US8884007B2 · kind B2 · utility

Assignee

• Institute of Pharmacology and Toxicology Medical Sciences P.L.A. China · CN

Inventors

• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Juan Liu · 安丰镇, CN
• Lili Wang · Beijing, CN
• Kunlun He · Baofeng County, CN
• Long Long · Beijing, CN
• Junhai Xiao · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Wei Li · Lexington, US
• Xin Li · Shanghai, CN
• Guoliang Hu · Nanchang, CN

Key dates

• Filing date: May 16, 2011
• Grant date: Nov 11, 2014
• Expiry date: May 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/194
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.