Process for the preparation of a mono-N-alkypiperazine

US8884015B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Roland Bou Chedid · Mannheim, DE
• Johann-Peter Melder · Schifferstadt, DE
• Ulrich Abel · Schifferstadt, DE
• Roman Dostalek · Neuleiningen, DE
• Bernd Stein · San Diego, US

Key dates

• Filing date: May 31, 2013
• Grant date: Nov 11, 2014
• Expiry date: Jun 3, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/03
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the preparation of a mono-N-alkylpiperazine of the formula Iin which R1 is C1- to C5-alkyl or 2-(2-hydroxyethoxy)ethyl,by reacting diethanolamine (DEOA) of the formula IIwith a primary amine of the formula H2N—R1 (III) in the presence of hydrogen and a supported, metal-containing catalyst, where the catalytically active mass of the catalyst, prior to its reduction with hydrogen, comprises oxygen-containing compounds of aluminum, copper, nickel and cobalt and, in the range from 0.2 to 5.0% by weight, oxygen-containing compounds of tin, calculated as SnO, and the reaction is carried out in the liquid phase at an absolute pressure in the range from 95 to 145 bar.