Process for preparing racemic nicotine

US8884021B2 · kind B2 · utility

Assignees

• TOPHARMAN SHANGHAI CO., LTD. · CN
• TOPHARMAN SHANDONG CO., LTD. · CN

Inventors

• Guanghui Tian · 安丰镇, CN
• Guan Wang · Shanghai, CN
• Xiaoguang Kong · Shanghai, CN
• Rongxia Zhang · Shanghai, CN
• Weiming Chen · Shanghai, CN
• Jingshan Shen · Shanghai, CN

Key dates

• Filing date: Jan 20, 2012
• Grant date: Nov 11, 2014
• Expiry date: Jan 20, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.