Process for preparing aminobenzoylbenzofuran derivatives

US8884033B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Xavier Bon · Paris, FR
• Christine Biencourt · Paris, FR
• Corinne Leroy · Paris, FR
• Julia Mateos-Caro · Paris, FR
• Philippe Vayron · Paris, FR

Key dates

• Filing date: Jan 16, 2013
• Grant date: Nov 11, 2014
• Expiry date: Jan 16, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula I:in which R1 and R2 are as defined in the disclosure; by reduction of a 5-nitrobenzofuran derivative of formula II:using a hydrogen transfer agent, in the presence of palladium-on-charcoal as catalyst and in an ether or an ether mixture as solvent.