Method for the production of antibodies

US8884096B2 · kind B2 · utility

Assignees

• Alexander Lifke · DE
• Valeria Lifke · DE
• Bernd Mueller-Beckmann · DE

Inventors

• Alexander Lifke · Penzberg, DE
• Valeria Lifke · Penzberg, DE
• Bernd Mueller-Beckmann · Grünstadt, DE
• Tobias Schnitzer · Munich, DE

Key dates

• Filing date: Mar 13, 2013
• Grant date: Nov 11, 2014
• Expiry date: Mar 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N5/0635
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.