Aromatic prenyltransferase from Cannabis
US8884100B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Aug 4, 2010 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Oct 30, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y205/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid molecules from Cannabis sativa (cannabis, hemp, marijuana) have been isolated and characterized, and encode polypeptides having aromatic prenyltransferase activity. Specifically, the enzyme, CsPT1, is a geranylpyrophosphate olivetolate geranyltransferase, active in the cannabinoid biosynthesis step of prenylation of olivetolic acid to form cannabigerolic acid (CBGA). Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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