Method and apparatus for motility contrast imaging
US8886295B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 2, 2010 |
| Grant date | Nov 11, 2014 |
| Priority date | — |
| Expiry date | Jan 1, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG03H2223/20
- WIPO fieldOptics
- WIPO sectorInstruments
Abstract
A system for motility contrast imaging a biological target within tissue comprising a CCD array; an illumination source for generating an incoming beam; a first beam splitter for receiving the incoming beam and producing an object beam and a reference beam; a second beam splitter for illuminating a multitude of biological targets with the object beam and for directing backscattered object beams towards the CCD array; a computer-controlled delay stage for zero-path-matching the reference beam to the backscattered object beams; a reference beam that intersects the backscattered object beams at an angle to produce a series of interference fringes that modulate Fourier-domain information; and a computer for receiving a time series of Fourier-domain information. The interference fringes between the backscattered object beam and the reference beam are recorded by the CCD array and passed to the computer which constructs a digital hologram at successive times.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.