Vaccine

US8889146B2 · kind B2 · utility

Assignee

• GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventors

• Ventzislav Bojidarov VASSILEV · Lincoln, US
• Virginie Van Scherpenzeel Thim · Rixensart, BE
• Normand Blais · Laval, CA
• Patrick Rheault · Oakville, CA

Key dates

• Filing date: Jun 24, 2010
• Grant date: Nov 18, 2014
• Expiry date: Sep 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18634
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides immunogenic compositions that include at least two paramyxovirus F protein antigens selected from human metapnuemovirus (hMPV), paarainfluenza virus (PIV) and respiratory syncytial virus (RSV). The antigens of the disclosed compositions are recombinant F protein polypeptides, which have been modified to stabilize the trimeric prefusion conformation. Nucleic acids encoding the antigens, as well as methods for their production and use are also provided.