Process of thermodynamical activation of water-insoluble drugs loaded into cross-linked polymers
US8889182B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jun 3, 2002 |
| Grant date | Nov 18, 2014 |
| Priority date | — |
| Expiry date | Apr 13, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/146
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention refers to a process to prepare a highly activated composite of one or more water-insoluble drugs, said process comprising the steps of: (a) subjecting said water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step a. to contact with water or water vapors. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from practically insoluble drug crystals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.