Sustained delivery of therapeutic agents to an eye compartment

US8889193B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Peter J. McDonnell · Baltimore, US
• Yasin A. Khan · Baltimore, US
• Samuel K. Lai · Carrboro, US
• Renata T. Kashiwabuchi · Baltimore, US
• Ashley Behrens · Baltimore, US
• Justin Hanes · Baltimore, US

Key dates

• Filing date: Feb 25, 2011
• Grant date: Nov 18, 2014
• Expiry date: Feb 25, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P27/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or IOP after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.