Method of determining inhibitors of coagulation

US8889370B2 · kind B2 · utility

Assignee

• Siemens Healthcare Diagnostics Products GmbH · DE

Inventors

• Andreas Kappel · Höhenkirchen-Siegertsbrunn, DE
• Andreas Rechner · Marburg, DE
• Sina Stephan · Marburg, DE
• Thomas Wissel · Marburg, DE

Key dates

• Filing date: Dec 21, 2011
• Grant date: Nov 18, 2014
• Expiry date: Jan 29, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.