Substituted triazoles useful as mGlu5 receptor modulators

US8889677B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Grauert · Ingelheim am Rhein, DE
• Daniel Bischoff · Grand Rapids, US
• Georg Dahmann · Biberach an der Riß, DE
• Raimund Kuelzer · Mittelbiberach, DE
• Klaus Rudolf · Warthausen, DE

Key dates

• Filing date: Jan 11, 2013
• Grant date: Nov 18, 2014
• Expiry date: Feb 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula Itheir use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.