Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof

US8889887B2 · kind B2 · utility

Assignees

• Dalian University of Technology · CN
• Dalian Firstar Information Materials Co., Ltd. · CN

Inventors

• Xiaojun Peng · Dalian, CN
• Zhigang Yang · Zhuhai, CN
• Yanxia He · Dalian, CN
• Jingyun Wang · 东风镇, CN
• Jiangli Fan · 东风镇, CN
• Shiguo Sun · Dalian, CN
• Fengling Song · Pittsburgh, US

Key dates

• Filing date: Jan 31, 2011
• Grant date: Nov 18, 2014
• Expiry date: Jan 31, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B23/08
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR7 and et al.; R3 and R4 are independently selected from the group consisting of CN, COOH and COOR16; R5, R6 and R7 are independently selected from the group consisting of H, SO3R10 and COOR11; R8 is H or C1-18 alkyl; R9 is H or CH3; R10 is N(R12R13R14R15); R11 is C1-18 alkyl; R12, R13, R14, R15 and R16 are independently selected from the group consisting of H, C1-18 alkyl, (CH2)mOR8 and (CHR9CH2O)pR8; Y− is halogen anion or OTs−; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells.