Compounds for use in therapy

US8889894B2 · kind B2 · utility

Assignees

• Bangor University · GB
• UNIVERSITEIT GENT · BE

Inventors

• Mark Stephen Baird · Blaenau Ffestiniog, GB
• Juma′ a Raheem Najeem Al-Dulayy-mi · Blaenau Ffestiniog, GB
• Cornelias Theunissen · Blaenau Ffestiniog, GB
• Gani Koza · Blaenau Ffestiniog, GB
• Seppe Vander-Beken · Evergem, BE
• Johan Grooten · Evergem, BE

Key dates

• Filing date: Apr 22, 2009
• Grant date: Nov 18, 2014
• Expiry date: Jan 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R2, R3 and R4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkenylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C—OR5; wherein R5 is alkyl or haloalkyl, and A is O, S or NR6, wherein R6 may be H or 20 alkyl.