Sustained release formulations using non-aqueous carriers

US8895033B2 · kind B2 · utility

Assignees

• Amylin Pharmaceuticals, LLC · US
• AstraZeneca Pharmaceuticals LP · US

Inventors

• Mary L. Houchin · Rockville, US
• Robin Lee · San Diego, US
• Hong Qi · East Lyme, US
• Greg Oehrtman · San Diego, US
• Robert Jennings · San Diego, US
• Scott H. Coleman · San Diego, US

Key dates

• Filing date: Sep 4, 2009
• Grant date: Nov 25, 2014
• Expiry date: Sep 18, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides one-component, injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.