Patent · US Active

Telodendrimer nanodiscs without apolipoprotein

US8895055B2 · kind B2 · utility

9Cited by

2References

21Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Kit S. Lam · Davis, US
Juntao Luo · Jamesville, US
Joyce S. Lee · Elk Grove, US

Key dates

Filing date	Dec 19, 2012
Grant date	Nov 25, 2014
Priority date	—
Expiry date	Dec 19, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/7048
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a nanodisc without a membrane scaffold protein. The nanodisc includes a telodendrimer and a lipid; the nanodisc does not include a membrane scaffold protein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Methods of making the nanodiscs are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.