Patent · US Active

Method of cell culture and method of treatment comprising a vEPO protein variant

US8895303B2 · kind B2 · utility

0Cited by

3References

11Claims

0Family size

Assignee

CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE

Inventors

Josef Priller · Berlin, DE
Christel Bonnas · Berlin, DE
Andreas Meisel · San Francisco, US

Key dates

Filing date	Nov 12, 2007
Grant date	Nov 25, 2014
Priority date	—
Expiry date	Jan 29, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2501/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

In one aspect the present invention is concerned with a method of cell culture, comprising the steps of (i) obtaining a stem or progenitor cell sample, (ii) culturing the stem or progenitor cell sample in media and under closed conditions appropriate to cause proliferation or differentiation of the stem or progenitor cells, wherein the media comprises a vEPO protein variant, (iii) purifying the stem or progenitor cells ex vivo. The invention relates to a method of increasing the number and survival of stem and progenitor cells in vitro and in vivo using a vEPO protein variant. The invention also relates to improved differentiation of stem and progenitor cells in vitro and in vivo using a vEPO protein variant.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.