Pyrrolidinones as MetAP-2 inhibitors

US8895535B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Timo Heinrich · Groß-Umstadt, DE
• Frank Zenke · Darmstadt, DE
• Michel Calderini · Darmstadt, DE
• Djordje Musil · Seeheim-Jugenheim, DE

Key dates

• Filing date: Sep 14, 2011
• Grant date: Nov 25, 2014
• Expiry date: Sep 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I in which R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.