Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
US8895695B2 · kind B2 · utility
9Cited by
1References
35Claims
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Key dates
| Filing date | Jul 1, 2010 |
| Grant date | Nov 25, 2014 |
| Priority date | — |
| Expiry date | Dec 30, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Template-fixed β-hairpin peptidomimetics of the general formula (I)wherein Z is a template-fixed chain of 12, 14 or 18 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.