Peptide-conjugated oligonucleotide therapeutic and method of making and using same
US8895701B2 · kind B2 · utility
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Key dates
| Filing date | Jul 2, 2010 |
| Grant date | Nov 25, 2014 |
| Priority date | — |
| Expiry date | Feb 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conjugates for the efficient delivery of sequence-specific antisense to cells of a selected type for the inhibition of a target protein have the general formula:peptide-HBL-antisensein which the peptide is a homing peptide which directs the conjugate to cells of a particular type, antisense is an antisense oligonucleotide having a sequence selected to provide sequence-specific inhibition of the target protein, and HBL is a heterobifunctional linker having reactivity towards amino and sulfhydryl groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.