Use of 9, 10-anthraquinone compounds

US8895725B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN
• INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Shuguang Wang · Shanghai, CN
• Jin Zhong · Shanghai, CN
• Deyun Kong · Shanghai, CN
• Jue Hu · Shanghai, CN
• Bo Li · Qinhuangdao City, CN
• Wen Gao · Plainsboro, US
• Chunyan Gai · Shanghai, CN
• Changlong Zhuang · Shanghai, CN
• Haitao Mao · Shanghai, CN

Key dates

• Filing date: Nov 23, 2009
• Grant date: Nov 25, 2014
• Expiry date: Jun 11, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.