Preparation process of (6R)-tetrahydrobiopterin hydrochloride
US8895735B2 · kind B2 · utility
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Key dates
| Filing date | Nov 15, 2010 |
| Grant date | Nov 25, 2014 |
| Priority date | — |
| Expiry date | Nov 15, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D475/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A preparation process of (6R)-tetrahydrobiopterin hydrochloride is provided, which comprises hydrogenating L-biopterin in the presence of a catalyst of Pt group metal in the basic substrate containing solvent, potassium hydroxide and potassium dihydrogen phosphate to obtain (6R)-tetrahydrobiopterin hydrochloride, wherein the pH value of the basic substrate is controlled by potassium hydroxide and potassium dihydrogen phosphate in the range of about 10 to about 13.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.