Methods for identifying inhibitors against viruses that use a class I fusion protein

US8898047B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Dirk André Emmy Roymans · Turnhout, BE
• Hendrik Leon Augusta Jozef De Bondt · Mechelen, BE
• Eric Pierre Alexandre Arnoult · Le Vaudreuil, FR
• Herman Van Vlijmen · Mechelen, BE
• Jean-François Bonfanti · Andé, FR

Key dates

• Filing date: Feb 26, 2009
• Grant date: Nov 25, 2014
• Expiry date: Oct 25, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/115
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention concerns the generation of a three dimensional model of the six helix bundle (6HB) complexed with an inhibitor and the use of that model to identify, screen and/or develop inhibitors against viruses that use a class I fusion protein. Such inhibitors of viruses that use a class I fusion protein may be effective for treating, for example, respiratory infections by Respiratory Syncytial Virus (RSV).