Compositions and soft tissue replacement methods

US8900571B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Dennis E. Van Epps · Cary, US
• Guang-Liang Jiang · Irvine, US
• Adam L. Collette · Westminster, US
• Rebecca L. Horan · Arlington, US
• Jingsong Chen · Virginia Beach, US
• Gregory H. Altman · Arlington, US
• Wha-Bin Im · Irvine, US

Key dates

• Filing date: Feb 16, 2012
• Grant date: Dec 2, 2014
• Expiry date: Sep 29, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K35/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structurewhere X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.