Immunoglobulin chimeric monomer-dimer hybrids

US8900827B2 · kind B2 · utility

Assignee

• Biogen Idec Hemophilia Inc. · US

Inventors

• Robert T. Peters · Needham, US
• Adam R. Mezo · Carmel, US
• Daniel S. Rivera · Providence, US
• Alan J. Bitonti · Acton, US
• James McGivney · Hagerstown, US
• Susan Low · Pepperell, US

Key dates

• Filing date: Nov 2, 2012
• Grant date: Dec 2, 2014
• Expiry date: Nov 2, 2032

Classification

• Technology area (CPC —): General

Abstract

The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.