Methods and nucleic acids for analyses of cellular proliferative disorders

US8900829B2 · kind B2 · utility

Assignee

• EPIGENOMICS AG · DE

Inventors

• Juergen Distler · Berlin, DE
• Thomas Hildmann · Berlin, DE
• Ralf Lesche · Berlin, DE
• Catherine E. Lofton-Day · Brier, US
• Fabian Model · Berlin, DE
• Matthias Schuster · Weinheim, DE
• Andrew Z. Sledziewski · Shoreline, US
• Reimo Tetzner · Berlin, DE
• Xiaoling Song · Woodinville, US

Key dates

• Filing date: Apr 28, 2011
• Grant date: Dec 2, 2014
• Expiry date: Apr 28, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.