Thiazolopyrimidine modulators as immunosuppressive agents

US8901132B2 · kind B2 · utility

Assignee

• Katholieke Universiteit Leuven, KU LEUVEN R&D · BE

Inventors

• Piet Herdewijn · Heverlee, BE
• Steven De Jonghe · Brussels, BE
• Ling-Jie Gao · Bierbeek, BE
• Mi Yeon Jang · Yongin-si, KR
• Bart Vanderhoydonck · Diest, BE
• Mark Waer · Heverlee, BE
• Yuan Lin · 流花街道, CN
• Jean Herman · Heverlee, BE
• Thierry Louat · Leuven, BE

Key dates

• Filing date: Mar 15, 2010
• Grant date: Dec 2, 2014
• Expiry date: May 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.