Pyrimidine derivatives

US8901143B2 · kind B2 · utility

Assignee

• Hutchison MediPharma Enterprises Limited · BS

Inventors

• Wei-Guo Su · Shanghai, CN
• Hong Jia · Beijing, CN
• Weihan Zhang · Shanghai, CN
• Yumin Cui · Shanghai, CN
• Xiaoqiang Yan · Shanghai, CN
• Yongxin Ren · Shanghai, CN
• Jifeng Duan · Shanghai, CN
• Yang Sai · Shanghai, CN

Key dates

• Filing date: Nov 8, 2012
• Grant date: Dec 2, 2014
• Expiry date: Dec 1, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the following formula:wherein R1, R2, R3, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.