Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide

US8901151B2 · kind B2 · utility

Assignee

• Targacept, Inc. · US

Inventors

• Merouane Bencherif · Winston-Salem, US
• Nikolai Fedorov · Winston-Salem, US
• Terry Hauser · Winston-Salem, US
• Kristen G. Jordan · Clemmons, US
• Sharon Rae Letchworth · Kernersville, US
• Anatoly Mazurov · Greensboro, US
• Julio A. Munoz · Walnut Cove, US
• Jason D. Speake · Durham, US
• Daniel Yohannes · Winston-Salem, US

Key dates

• Filing date: May 14, 2013
• Grant date: Dec 2, 2014
• Expiry date: May 14, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).