Useful combinations of monobactam antibiotics with beta-lactamase inhibitors

US8901293B2 · kind B2 · utility

Assignee

• Basilea Pharmaceutica AG · CH

Inventors

• Eric Desarbre · Mulhouse, FR
• Berangere Gaucher · Mulhouse, FR
• Malcolm Page · Basel, CH
• Patrick Roussel · Thiais, FR

Key dates

• Filing date: Dec 7, 2006
• Grant date: Dec 2, 2014
• Expiry date: Aug 21, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New monobactam antibiotics compounds which contain an 3-amino-azetidin-2-one ring and are active against gram-negative bacteria, wherein the compounds include the compound 2-(2-amino-thiazol-4-yl)-2-[(Z)-(1H,4H-1,5-dihydroxy-4-oxo-pyridin-2-yl)methoxyimino]-N-[3(S)-1-oxysulfonyl-2,2-dimethyl-4-oxo-azetidin-3-yl]acetamide.