Crystalline forms of cabazitaxel and process for preparation thereof

US8901322B2 · kind B2 · utility

Assignee

• Fresenius Kabi Oncology Ltd. · IN

Inventors

• Saswata Lahiri · Sindhar, IN
• Rajesh Srivastava · Manesar, IN
• Bhuwan Bhaskar Mishra · Manesar, IN
• Shatrughan Sharma · Manesar, IN
• Vijay Ojha · Manesar, IN
• Nilendu Panda · Barwala, IN
• Sandeep Kumar · Spring, US
• Sonu Prasad · Manesar, IN

Key dates

• Filing date: Nov 21, 2012
• Grant date: Dec 2, 2014
• Expiry date: Nov 21, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides Crystalline Forms of 4-acetoxy-2α-benzoyloxy-5β-20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxotax-11-en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, i.e Cabazitaxel. The present invention also discloses methods for the preparation of Crystalline Forms of Cabazitaxel and pharmaceutical compositions thereof.