Patent · US Active

Subcellular analysis by laser ablation electrospray ionization mass spectrometry

US8901487B2 · kind B2 · utility

0Cited by
28References
20Claims
0Family size

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Inventors

Key dates

Filing dateMar 10, 2011
Grant dateDec 2, 2014
Priority date—
Expiry dateMay 9, 2031

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2001/045
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.