Microelectrode arrays

US8901913B2 · kind B2 · utility

Assignee

• CAPITALBIO CORPORATION · CN

Inventors

• Jing-Lei Zhu · Beijing, CN
• Zhongyao Yu · Beijing, CN
• Xueling Quan · Beijing, CN
• Guangxin Xiang · Beijing, CN
• Yuming Hu · Beijing, CN
• Wanli Xing · Beijing, CN
• Jing Cheng · Beijing, CN

Key dates

• Filing date: Apr 16, 2009
• Grant date: Dec 2, 2014
• Expiry date: Jun 17, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/4836
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Among others things, techniques, systems, and apparatus are disclosed for recording electrophysiological signals. In one aspect, a microelectrode sensing device includes a printed circuit board (PCB), a chip unit electrically connected to the PCB, and a cell culture chamber positioned over the chip unit and sealed to the PCB with the chip unit between the PCB and the cell culture chamber. The chip unit includes a substrate; a conductive layer positioned over the substrate that includes one or more recording electrodes; an insulation layer positioned over the conductive layer; another conductive layer positioned over the insulation layer that includes positioning electrodes; and another insulation layer positioned over the other conductive layer. The recording and positioning electrodes are electrically independent so as to independently receive a stimulus signal at each recording electrode and positioning electrode and independently detect a sensed signal at each recording electrode.