Mutant proteins of the F protein of PIV-5 and PIV-2

US8906386B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• UNIVERSITE CLAUDE BERNAD LYON 1 · FR
• Les Hospices Civils de Lyon · FR

Inventors

• Manuel Melchior Jean-Pierre Rosa Calatrava · Val-de-Reuil, FR
• Olivier Terrier · Val-de-Reuil, FR
• Francois Edouard Julien Durupt · Val-de-Reuil, FR

Key dates

• Filing date: Nov 17, 2009
• Grant date: Dec 9, 2014
• Expiry date: Sep 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18722
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application concerns mutant proteins of the fusion protein (F protein) of the parainfluenza virus (PIV) which are currently indexed as type 5 PIV (PIV-5 or PIV5) and type 2 PIV (PIV-2 or PIV2). The present application concerns products deriving therefrom, such as: nucleic acids, vectors, cells, fusion inhibitors of the antibody, aptamer, interfering RNA type; myelomas, hybridomas; stem and progenitor cells. The present application also concerns mutant proteins and products derived therefrom for use in medical and biotechnological applications.